#1 choler n. [irritability, crossness, fretfulness, fussiness, peevishness, petulance] an irritable petulant feeling. wn #2 choler n. [anger, ire] a strong emotion; a feeling that is oriented toward some real or supposed grievance. wn #3 choler n. [yellow bile] a humor that was once believed to be secreted by the liver and to cause irritability and anger. wn