#1 give up v. lose (s.th.) or lose the right to (s.th.) by some error, offense, or crime; "you've forfeited your right to name your successor"; "forfeited property". wn #2 give up v. give up with the intent of never claiming again; "Abandon your life to God"; "She gave up her children to her ex-husband when she moved to Tahiti"; "We gave the drowning victim up for dead". wn #3 give up v. give up in the face of defeat of lacking hope; admit defeat; "In the second round, the challenger gave up". wn #4 give up v. put an end to a state or an activity; "Quit teasing your little brother". wn #5 give up v. give up what is not strictly needed; "he asked if they could spare one of their horses to speed his journey". wn