#1 irritation n. [annoyance, vexation, botheration] the psychological state of being irritated or annoyed. wn
#2 irritation n. [pique, temper] a sudden outburst of anger; "his temper sparked like damp firewood". wn
#3 irritation n. (pathology) abnormal sensitivity to stimulation; "any food produced irritation of the stomach". wn
#4 irritation n. [excitation, innervation] the neural or electrical arousal of an organ or muscle or gland. wn
#5 irritation n. [discomfort, soreness] an uncomfortable feeling of mental painfulness or distress. wn
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