#1 substance n. the real physical matter of which a person or thing consists; "DNA is the substance of our genes". wn
#2 substance n. [kernel, core, center, centre, essence, gist, heart, heart and soul, inwardness, marrow, meat, nub, pith, sum, nitty-gritty] the choicest or most essential or most vital part of some idea or experience; "the gist of the prosecutor's argument"; "the heart and soul of the Republican Party"; "the nub of the story". wn
#3 substance n. [meaning] the idea that is intended; "What is the meaning of this proverb?". wn
#4 substance n. material of a particular kind or constitution; "the immune response recognizes invading substances". wn
#5 substance n. [means] considerable capital (wealth or income); "he is a man of means". wn
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